Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
5ht2a_human 306 ICL3 Y => Ter stop gained 1.649e-05 2 121254 0 None None
5ht2a_human 280 ICL3 S => LeufsTer56 frameshift 8.25e-06 1 121218 0 None None PTM (Phosphorylation)
5ht2a_human 53 N-term T => AsnfsTer58 frameshift 6.061e-05 1 16498 0 None None
5ht2a_human 467 C-term K => N missense 8.43e-06 1 118628 0 nan 0.009
5ht2a_human 465 C-term N => D missense 8.368e-06 1 119504 0 nan 0.004
5ht2a_human 463 C-term G => R missense 8.328e-06 1 120074 0 0.53 0.079
5ht2a_human 462 C-term D => N missense 3.32e-05 4 120470 0 nan 0.001
5ht2a_human 460 C-term N => S missense 8.275e-06 1 120842 0 nan 0.002
5ht2a_human 454 C-term E => Q missense 8.252e-06 1 121186 0 nan 0.276
5ht2a_human 453 C-term S => C missense 3.3e-05 4 121196 0 nan 0.004
5ht2a_human 453 C-term S => T missense 8.249e-06 1 121226 0 0.57 0.003
5ht2a_human 452 C-term H => L missense 8.248e-06 1 121238 0 nan 0.002
5ht2a_human 452 C-term H => Y missense 0.07896 9574 121246 429 nan 0.178
5ht2a_human 450 C-term K => E missense 8.245e-06 1 121286 0 nan 0.037
5ht2a_human 447 C-term A => V missense 0.001484 180 121296 0 nan 0.003
5ht2a_human 447 C-term A => T missense 6.596e-05 8 121294 0 nan 0.001
5ht2a_human 446 C-term V => A missense 8.244e-06 1 121298 0 nan 0.002
5ht2a_human 443 C-term C => G missense 8.242e-06 1 121324 0 0.33 0.002
5ht2a_human 436 C-term A => G missense 1.648e-05 2 121336 0 nan 0.006
5ht2a_human 434 C-term Q => R missense 8.241e-06 1 121342 0 nan 0.0
5ht2a_human 424 C-term L => F missense 8.241e-06 1 121350 0 0.01 0.894
5ht2a_human 421 C-term S => Y missense 8.241e-06 1 121350 0 0.01 0.999
5ht2a_human 419 C-term Y => C missense 3.297e-05 4 121338 0 nan 0.019 PTM (Phosphorylation)
5ht2a_human 415 C-term P => L missense 8.241e-06 1 121344 0 0.06 0.999
5ht2a_human 410 C-term L => I missense 1.648e-05 2 121328 0 nan 0.998
5ht2a_human 409 C-term I => F missense 8.242e-06 1 121332 0 nan 0.099
5ht2a_human 401 C-term E => Q missense 8.246e-06 1 121270 0 0.23 0.953
5ht2a_human 400 C-term K => Q missense 8.247e-06 1 121258 0 0.24 0.029
5ht2a_human 393 8.56x56 H8 R => Q missense 1.65e-05 2 121196 0 0.01 0.998
5ht2a_human 386 8.49x49 H8 T => N missense 8.252e-06 1 121188 0 0.0 0.999 GP (contact)
5ht2a_human 363 7.36x35 TM7 N => K missense 2.475e-05 3 121214 0 0.04 0.312 LB (Van der Waals)
5ht2a_human 358 7.31x30 TM7 I => T missense 8.247e-06 1 121252 0 0.0 0.234
5ht2a_human 355 7.28x27 TM7 E => K missense 8.246e-06 1 121278 0 0.41 0.047
5ht2a_human 351 ECL3 E => G missense 8.245e-06 1 121292 0 0.3 0.086
5ht2a_human 348 6.60x60 TM6 I => V missense 1.649e-05 2 121310 0 0.24 0.005
5ht2a_human 347 6.59x59 TM6 V => I missense 2.473e-05 3 121314 0 0.0 0.998
5ht2a_human 344 6.56x56 TM6 I => V missense 8.242e-06 1 121328 0 0.93 0.007
5ht2a_human 339 6.51x51 TM6 F => C missense 8.242e-06 1 121326 0 0.0 0.999 LB (hydrophobic, Van der Waals, aromatic (edge-to-face))
5ht2a_human 333 6.45x45 TM6 V => M missense 8.243e-06 1 121318 0 0.0 1.0 LB (hydrophobic, Van der Waals)
5ht2a_human 330 6.42x42 TM6 F => L missense 8.243e-06 1 121316 0 0.14 0.365
5ht2a_human 328 6.40x40 TM6 V => I missense 3.297e-05 4 121306 0 0.0 0.998 GP (contact)
5ht2a_human 312 6.24x24 TM6 M => V missense 2.474e-05 3 121266 0 0.15 0.986
5ht2a_human 310 ICL3 R => T missense 8.247e-06 1 121252 0 0.02 0.907
5ht2a_human 307 ICL3 T => R missense 8.247e-06 1 121260 0 0.53 0.075
5ht2a_human 305 ICL3 S => F missense 8.247e-06 1 121252 0 0.0 0.169 PTM (Phosphorylation)
5ht2a_human 304 ICL3 G => E missense 8.247e-06 1 121252 0 0.18 0.016
5ht2a_human 303 ICL3 P => L missense 6.598e-05 8 121244 0 0.16 0.001
5ht2a_human 302 ICL3 E => K missense 2.474e-05 3 121240 0 0.42 0.528
5ht2a_human 297 ICL3 R => Q missense 4.125e-05 5 121208 0 0.15 0.753
5ht2a_human 297 ICL3 R => W missense 1.65e-05 2 121194 0 0.02 0.997
5ht2a_human 296 ICL3 Q => R missense 8.25e-06 1 121214 0 0.56 0.057
5ht2a_human 294 ICL3 L => R missense 8.249e-06 1 121226 0 0.09 0.989
5ht2a_human 294 ICL3 L => I missense 8.249e-06 1 121224 0 0.16 0.83
5ht2a_human 287 ICL3 S => G missense 8.25e-06 1 121216 0 0.09 0.057 PTM (Phosphorylation)
5ht2a_human 284 ICL3 L => F missense 8.25e-06 1 121216 0 0.17 0.023
5ht2a_human 280 ICL3 S => P missense 8.25e-06 1 121218 0 0.12 0.838 PTM (Phosphorylation)
5ht2a_human 277 ICL3 K => R missense 1.65e-05 2 121220 0 0.34 0.855
5ht2a_human 275 ICL3 R => P missense 8.25e-06 1 121212 0 0.04 0.932
5ht2a_human 275 ICL3 R => Q missense 8.25e-06 1 121212 0 0.11 0.587
5ht2a_human 275 ICL3 R => W missense 2.475e-05 3 121216 0 0.0 0.971
5ht2a_human 274 ICL3 T => I missense 1.65e-05 2 121216 0 0.1 0.055
5ht2a_human 271 5.75x75 TM5 D => Y missense 3.3e-05 4 121216 0 0.01 0.748 GP (contact)
5ht2a_human 258 5.62x62 TM5 I => V missense 1.65e-05 2 121196 0 0.25 0.996
5ht2a_human 255 5.59x59 TM5 F => L missense 8.251e-06 1 121200 0 0.25 0.781
5ht2a_human 245 5.49x49 TM5 I => T missense 8.252e-06 1 121184 0 0.09 0.761
5ht2a_human 245 5.49x49 TM5 I => N missense 8.252e-06 1 121184 0 0.0 0.942
5ht2a_human 241 5.45x46 TM5 V => M missense 8.253e-06 1 121162 0 0.05 0.965
5ht2a_human 235 5.39x40 TM5 V => I missense 8.254e-06 1 121150 0 0.34 0.194 LB (hydrophobic, Van der Waals)
5ht2a_human 234 5.38x39 TM5 F => C missense 8.254e-06 1 121148 0 0.0 0.996 LB (hydrophobic, Van der Waals)
5ht2a_human 230 ECL2 A => T missense 0.0001156 14 121120 0 0.9 0.009
5ht2a_human 224 ECL2 E => G missense 1.653e-05 2 120998 0 0.03 0.004
5ht2a_human 222 ECL2 F => L missense 8.273e-06 1 120882 0 0.12 0.996
5ht2a_human 221 ECL2 V => F missense 8.277e-06 1 120820 0 0.02 0.937
5ht2a_human 218 ECL2 D => N missense 2.49e-05 3 120492 0 0.29 0.843
5ht2a_human 214 4.64x65 TM4 G => V missense 8.336e-06 1 119966 0 0.0 1.0
5ht2a_human 210 4.60x61 TM4 I => V missense 8.416e-06 1 118816 0 0.21 0.007 LB (hydrophobic, Van der Waals)
5ht2a_human 197 4.47x47 TM4 I => T missense 8.236e-06 1 121412 0 0.16 0.214
5ht2a_human 197 4.47x47 TM4 I => V missense 0.006499 789 121412 27 0.72 0.536
5ht2a_human 185 34.55x55 ICL2 R => H missense 1.647e-05 2 121412 0 0.05 1.0 GP (contact)
5ht2a_human 175 3.52x52 TM3 V => I missense 1.647e-05 2 121412 0 1.0 0.016
5ht2a_human 173 3.50x50 TM3 R => C missense 8.236e-06 1 121412 0 0.0 1.0 SodiumPocket MicroSwitch GP (contact)
5ht2a_human 168 3.45x45 TM3 A => T missense 8.236e-06 1 121412 0 0.02 1.0
5ht2a_human 155 3.32x32 TM3 D => E missense 8.237e-06 1 121404 0 0.0 0.999 LB (polar (charge-assisted hydrogen bond), polar (charge-charge))
5ht2a_human 140 23.49x49 ECL1 R => Q missense 1.65e-05 2 121248 0 0.55 0.005
5ht2a_human 126 2.56x551 TM2 L => V missense 8.295e-06 1 120552 0 0.01 0.765
5ht2a_human 118 2.48x48 TM2 I => V missense 8.251e-06 1 121202 0 1.0 0.164
5ht2a_human 102 1.60x60 TM1 E => K missense 8.237e-06 1 121408 0 0.0 0.999
5ht2a_human 97 1.55x55 TM1 M => T missense 8.237e-06 1 121410 0 0.0 0.438
5ht2a_human 95 1.53x53 TM1 V => I missense 8.237e-06 1 121408 0 0.0 0.998
5ht2a_human 93 1.51x51 TM1 I => T missense 8.237e-06 1 121410 0 0.03 0.999
5ht2a_human 83 1.41x41 TM1 V => I missense 1.647e-05 2 121410 0 0.83 0.002
5ht2a_human 78 1.36x36 TM1 A => V missense 8.237e-06 1 121410 0 0.01 0.905
5ht2a_human 76 1.34x34 TM1 W => L missense 8.237e-06 1 121410 0 0.0 0.998
5ht2a_human 68 N-term L => F missense 8.237e-06 1 121410 0 0.72 0.002
5ht2a_human 60 N-term C => F missense 8.237e-06 1 121410 0 nan 0.005
5ht2a_human 60 N-term C => Y missense 8.237e-06 1 121410 0 1.0 0.0
5ht2a_human 52 N-term R => Q missense 2.471e-05 3 121410 0 0.49 0.001
5ht2a_human 48 N-term D => N missense 6.589e-05 8 121410 0 0.37 0.001
5ht2a_human 46 N-term T => I missense 8.236e-06 1 121412 0 0.0 0.996
5ht2a_human 40 N-term S => T missense 8.237e-06 1 121410 0 0.24 0.411
5ht2a_human 38 N-term N => K missense 8.237e-06 1 121404 0 0.01 0.255
5ht2a_human 31 N-term D => Y missense 1.647e-05 2 121398 0 nan 0.172
5ht2a_human 30 N-term N => Y missense 5.766e-05 7 121394 0 nan 0.033
5ht2a_human 29 N-term S => G missense 8.238e-06 1 121390 0 nan 0.002
5ht2a_human 25 N-term T => N missense 0.01854 2250 121354 24 nan 0.01
5ht2a_human 25 N-term T => S missense 3.296e-05 4 121354 0 nan 0.0
5ht2a_human 24 N-term D => N missense 8.243e-06 1 121322 0 nan 0.001
5ht2a_human 23 N-term D => G missense 8.243e-06 1 121316 0 nan 0.0
5ht2a_human 21 N-term L => I missense 8.246e-06 1 121264 0 nan 0.001
5ht2a_human 19 N-term M => I missense 1.65e-05 2 121218 0 nan 0.0
5ht2a_human 17 N-term S => T missense 8.272e-06 1 120894 0 nan 0.001
5ht2a_human 15 N-term T => M missense 8.292e-06 1 120602 0 nan 0.001
5ht2a_human 14 N-term T => I missense 8.308e-06 1 120366 0 nan 0.001
5ht2a_human 14 N-term T => A missense 1.663e-05 2 120290 0 nan 0.001
5ht2a_human 12 N-term S => N missense 0.0008264 99 119802 3 1.0 0.0


Residue

Diagrams

ICL1 K K L Q ICL1ECL1 Y R W P L ECL1ICL2 P I H H S R F N ICL2ECL2 D S K V F K E G S C L L A ECL2ICL3 G T R A K L A S F S F L P Q S S L S S E K L F Q R S I H R E P G S Y T G R R T ICL3ECL3 K E S C ECL3N-term M D I L C E E N T S L S S T T N S L M Q L N D D T R L Y S N D F N S G E A N T S D A F N W T V D S E N R T N L S C E G C L S P S C L S L N-termC-term Q Y K E N K K P L Q L I L V N T I P A L A Y K S S Q L Q M G Q K K N S K Q D A K T T D N D C S M V A L G K Q H S E E A S K D N S D G V N E K V S C V C-term L H L Q E K N W S A L L T A V V I I L T I A G N I L V I M A V S L E N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N S R T K A F L K I I A V W T I S V G I S M P I P V F G L Q D D D N F V L I G S F V S F F I P L T I M V I T Y F L T I K S L Q K E A T L C V S D L M Q S I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C N E D V I G A L L N V F V W I G Y L S S A V N P L V Y T L F N K T F S R Y R S A Y I Q C
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